2. Space Time Trends of Community Onset Staphylococcus aureus Infections in Children Living in Southeastern United States: 2002-2016

Abstract Background Staphylococcus aureus (S. aureus) remains a serious cause of infections in the United States and worldwide. Methicillin susceptible S. (MSSA) is half all health care–associated staphylococcal infections, Resistant (MRSA) leading community onset skin soft tissue US. This study looks at 15-year trend (CO)-MRSA MSSA determines ‘best’ to ‘worst’ infection trends. We identified distinct groups CO-MRSA rate trajectories by grouping census tracts 20 county Atlanta Metropolitan Statistical Area (MSA) between 2002 2016 with similar temporal trajectories. Methods retrospective from 2002-2016, using electronic records children living Atlanta, Georgia relevant US data (at tract level). A group based trajectory model was applied generate (low, high, very high) were mapped ArcGIS. Results Three CO-MSSA two detected among 909 counties. found ~74% S.aureus occurrence during this time period belonged low for both MRSA MSSA, higher proportion occurring less densely populated Census DeKalb County, one Atlanta’s most areas, had highest worst patterns (CO-MRSA high or high). Trends Community-Onset Infection Rates Based on Group-based Trajectory Models Spatial Between Conclusion patterns, stratified antibiotic resistance over geographic areas time, identify communities risks compared infection. Further investigation determinants groupings outliers may be way target prevention strategies aimed prevent infections. Disclosures All Authors: No reported disclosures